DNA condensation at the single molecule level monitored using optical tweezers
DNA condensation at the single molecule level monitored using optical tweezers
Last Updated on Saturday, 30 July 2011 07:43 Written by Administrator Saturday, 30 July 2011 07:43
This movie shows DNA condensation by a positively charged peptide polymer. The top bead is “tweezed” by a laser light and the bottom bead is fixed onto the pipette tip. There is a single DNA molecule connecting the two beads at a 3 pN force level. As the positively charged peptide polymer binds to the negatively charged DNA, it condenses the DNA into a compact form, which is demonstrated by reduction of the distance between the beads.
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