Gain of Function Mutations
In gain of function mutations, a protein takes on a new function or the protein loses the ability to be regulated by other proteins. These mutations are dominant since the new function may be deleterious (harmful) even in the presence of a normal protein that is encoded by the other gene copy that does not have the mutant. The dominant allele is related to gain of function mutation. Gain of function mutations change the gene product such that it gains a new and abnormal function. These mutations have dominant phenotypes. These mutations are usually called neomorphic mutation.
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